FURTHER EVIDENCE FOR INDUCIBILITY OF STAPHYLOCOCCAL PENICILLINASE
نویسندگان
چکیده
منابع مشابه
Substrate-specific inactivation of staphylococcal penicillinase.
1. The rate of hydrolysis of methicillin, cloxacillin and quinacillin by staphylococcal extracellular penicillinase decreases progressively with time. 2. The inactivation is prevented but not reversed by benzylpenicillin. 3. The rate of inactivation produced by quinacillin is minimal when the rate of hydrolysis is at a maximum. 4. Under certain conditions, partially inactivated enzyme can be re...
متن کاملInteraction of Staphylococcal Penicillinase and 6-[D(-
Citri and Zyk (3) recently showed that the penicillinase of Bacillus cereus, on interaction with substrates, may yield conformational changes at the active site of the enzyme. Earlier studies by a number of investigators (1, 2, 4, 6, 8, 11) showed that penicillin analogues resistant to staphylococcal penicillinase, such as methicillin, may cause inactivation ofthe enzyme. In contrast, Richmond ...
متن کاملRegulation of penicillinase synthesis: a mutation in Staphylococcus aureus unlinked to the penicillinase plasmid that reduced penicillinase inducibility.
A mutant of Staphylococcus aureus strain 655 was isolated that is restricted in penicillinase induction. Wild-type plasmids that bear penicillinase determinants could not be fully induced in this mutant, 655par-1; hence, the responsible mutation is not located on the plasmid. Mutant plasmid PI(258)penI443, which produces penicillinase constitutively in wild-type cells, was fully constitutive fo...
متن کاملIn Vivo Studies on Staphylococcal Penicillinase.
Eyckmans, Luc (Baylor University Medical Center, Dallas, Tex.), and Ralph Tompsett. In vivo studies on staphylococcal penicillinase. J. Bacteriol. 90:589-593. 1965.-The amounts of staphylococcal penicillinase present in tissue of mice with well-established infections due to penicillin-resistant staphylococci were determined. The data indicate that, in the presence of such infection, penicillina...
متن کاملRegulation of Penicillinase Synthesis : a Mutation in Staphylococcus aureus Unlinked to the Penicillinase Plasmid That Reduces Penicillinase Inducibility
A mutant of Staphylococcus aureus strain 655 was isolated that is restricted in penicillinase induction. Wild-type plasmids that bear penicillinase determinants could not be fully induced in this mutant, 655par-1; hence, the responsible mutation is not located on the plasmid. Mutant plasmid PI258 penI443, which produces penicillinase constitutively in wild-type cells, was fully constitutive for...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1958
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.76.1.117-118.1958